Research-Grade
Oligonucleotide Manufacturing
Our Aji Bio-Pharma GeneDesign team brings more than 25 years of experience in solid-phase oligonucleotide synthesis, with deep expertise across a wide range of sequences and chemistries. Our specialists support oligonucleotides from short to long sequences, including complex and highly modified molecules, delivering high purity, consistent quality, and reliable, on-time delivery.
Oligonucleotide Manufacturing for Early Research
Our solid-phase research-grade manufacturing capabilities support early-stage oligonucleotide research from µg and mg quantities through gram scale. Our services support compound screening and detection applications, method development for difficult-to-synthesize products such as long-chain RNA, and the development of modified oligonucleotides incorporating PEGs, peptides, or lipids. We also develop processes and methods that can support progression to larger-scale production.
Complexity Without Compromise
For therapeutic developers in rare diseases, oncology, and CNS, we bring the synthesis expertise, flexibility, and quality needed to move challenging programs forward.
Technology Continuity & Conjugation
From early development through commercialization, our integrated capabilities provide manufacturing continuity as programs scale. Our expertise also extends to conjugate programs, including AOC through ADC conjugation, GalNAc-ASO, GalNAc-siRNA, and PPMO.
Process Development & Scale-Up
We enable a seamless path from early development to clinical and commercial manufacturing through integrated process development and in-house manufacturing capabilities. From synthesis optimization and purification to lyophilization, our end-to-end expertise supports every stage of the workflow with consistency and efficiency.
Analytical & Quality Systems
Integrated analytical and quality systems support comprehensive in-house characterization and release testing for oligonucleotide programs. Our analytical platform includes LC-MS for identity testing, LC-MS/MS for sequence confirmation, RP-IP-HPLC for purity and assay, RP-IP-HPLC and AEX-HPLC for related substances, GC for residual solvents, colorimetric LAL assays for endotoxin, and calibrated pH measurement.
Chemistry Capabilities & Modified Oligonucleotides
Unlocking Momentum in Complex Oligos Development
Our solid-phase expertise helps enable complex oligonucleotide designs and modifications that can present significant development challenges. Through proprietary know-how and multi-step modification capabilities, we help therapeutic developers address technical barriers and advance highly complex molecules through discovery, lead optimization, and early development. By combining deep chemistry expertise with a collaborative approach, our team helps solve complex development challenges and establish a more reliable path from concept to candidate.
25+
Years of oligo synthesis experience
100+
Unique modifications supported
95.3%
Purity achieved on 100-mer sgRNA
560
Maximum chain length
Solutions for Every Need
We are one of the only CDMOs offering both traditional solid-phase and proprietary AJIPHASE™ liquid-phase synthesis from development through commercial supply.
Manufacturing Infrastructure
Our GeneDesign site in Osaka supports solid-phase oligonucleotide synthesis from research-grade through GMP manufacturing. With process development and manufacturing capabilities all under one roof, our team supports a smooth transition to GMP manufacturing as programs advance toward clinical development.
Let’s Discuss Your Complex
Oligo Synthesis Needs
Complex oligonucleotide modifications are our daily practice
Frequently Asked Questions
What modified oligonucleotide chemistries does Ajinomoto Bio-Pharma Services support?
Ajinomoto Bio-Pharma Services offers a broad portfolio of modified oligonucleotide chemistries, including PS, PMO, 2′-F, 2′-OMe, 2′-MOE, LNA, GalNAc, cholesterol, peptide, and antibody conjugates.
With extensive experience in a wide range of additional modifications, Aji Bio-Pharma can also accommodate chemistries beyond those listed in their price list. If you have a specific modification in mind, contact the team to discuss your requirements.
How should Ajinomoto Bio-Pharma Services‘ DNA/RNA products be dissolved and stored?
Ajinomoto Bio-Pharma Services’ products are supplied in lyophilized form. Before use, dissolve them in an aqueous solvent appropriate for your experimental system. No particular solvent is recommended; depending on your application, sterile water, nuclease-free water, TE buffer, or other suitable buffers may be used.
For storage, Aji Bio-Pharma experts recommend keeping the products at −20°C or below. After reconstitution, the solution should be aliquoted for storage, and repeated freeze–thaw cycles should be avoided.
Does Ajinomoto Bio-Pharma Services support GalNAc conjugation and specialized modifications such as 5′-vinylphosphonate?
Yes. Ajinomoto Bio-Pharma Services supports both GalNAc conjugation and specialized modifications such as 5′-vinylphosphonate modification. Since multiple GalNAc structures are available, please specify the structure you require. The most commonly requested options are listed in Aji Bio-Pharma’s products list.
Can Ajinomoto Bio-Pharma Services synthesize 100-mer or longer oligonucleotides?
Yes. Ajinomoto Bio-Pharma Services routinely supports the synthesis of oligonucleotides exceeding 100-mer in length. Oligonucleotides up to approximately 100–120 mer can be produced using conventional solid-phase synthesis. For longer RNA, Aji Bio-Pharma offers GenClip™, an advanced approach combining chemical synthesis with enzymatic ligation. mRNA up to 560 mer has been successfully synthesized using GenClip™.
For RNA in the 80–120 mer range, Aji Bio-Pharma experts will recommend the most suitable synthesis method—conventional solid-phase synthesis or GenClip™—based on the sequence.
What is the relationship between solid-phase synthesis and AJIPHASE™ for complex oligonucleotides?
Solid-phase synthesis is used from early, small-quantity studies up to kilogram-scale production, while AJIPHASE™ is applied for tens-of-kilograms to ton-scale manufacturing. When appropriate, Ajinomoto Bio-Pharma Services also leverages GenClip™, which combines enzymatic ligation, to support the overall process.
In what form are Ajinomoto Bio-Pharma Services oligonucleotide products delivered?
Ajinomoto Bio-Pharma Services supplies oligonucleotides in lyophilized form.
What is the typical turnaround time for Ajinomoto Bio-Pharma Services oligonucleotide products?
For oligonucleotides of around 30 mer, delivery is typically within 1–2 weeks. Larger-scale or more complex oligonucleotides may require additional time, but most products are delivered within 1 month.
What payment methods does Ajinomoto Bio-Pharma Services accept for product orders?
Ajinomoto Bio-Pharma Services accepts orders from customers worldwide.
For customers in Japan, transactions are handled through our distributors.
Customers outside Japan can purchase directly from us. Payment can be made by bank transfer or credit card. Japanese yen (JPY) and U.S. dollars (USD) are the primary currencies available, with additional currencies available for certain orders. Contact the Aji Bio-Pharma team if you require a specific currency.
How much does shipping cost for Ajinomoto Bio-Pharma Services oligonucleotide products?
Unless otherwise requested, Ajinomoto Bio-Pharma Services covers shipping costs for both domestic and international orders.
Does Ajinomoto Bio-Pharma Services offer any promotions or discounts on oligonucleotide product orders?
Yes. Ajinomoto Bio-Pharma Services offers a 10% discount when 16 or more oligonucleotides are ordered at the same time. Academic customers are also eligible for discounted academic pricing.
Contact the Aji Bio-Pharma GeneDesign team for a quote and details on available discounts.