Oligonucleotide Manufacturing
We support oligonucleotide development and manufacturing from research through commercial scale by combining the broad modality support of solid-phase synthesis with the scalability of our proprietary liquid-phase technology, AJIPHASE™. Supported by scientific and regulatory expertise, manufacturing infrastructure, and flexible operations, we help customers move programs from early development to commercial supply.
Your Oligonucleotide Partner from Research to Commercial
From early development to commercial supply, we provide seamless manufacturing within a consistent quality framework. As programs scale, support stays with our experts, avoiding the need for a CDMO switch.
Research Grade
We manufacture and supply ASOs, siRNAs, and a variety of modified oligonucleotides, produced under stringent quality specifications to support research programs that require reliable material.
Clinical Phase
We provide a full-service offering spanning process and analytical development, from the first GMP batch through late-stage clinical programs, helping advance programs efficiently.
Commercial Production
We support customers as a long-term API supply partner, planning and executing process characterization packages and PPQ activities required for regulatory approval.
Enabling a Wide Range of Specialized Oligo Development
We combine deep expertise in complex oligonucleotide chemistry, the scalability of the AJIPHASE™ synthesis platform, and global regulatory expertise to support efficient development, manufacturing, and commercialization across the oligonucleotide lifecycle.
Custom DNA/RNA Oligonucleotides
Custom DNA synthesis for aptamers, molecular probes, diagnostics, and research applications.
Phosphorodiamidate Morpholino Oligonucleotides
Exon-skipping therapeutic programs for Duchenne muscular dystrophy (DMD).
Oligonucleotide Conjugates
Targeted delivery conjugates including GalNAc-ASO/siRNA, dye-labeled oligos, and antibody-oligonucleotide conjugates.
Antisense Oligonucleotides
Gene silencing and splice-switching programs from preclinical through commercial GMP supply.
Small Interfering RNA
RNAi therapeutics across research-grade through GMP clinical manufacturing scales.
MicroRNA Modulators
MicroRNA and antagomir synthesis for oncology and cardiovascular therapeutic programs.
Technology at a Glance
Based on each customer’s development stage, scale, and program needs, we recommend the optimal approach: Solid-Phase, AJIPHASE™ Synthesis, Enzymatic siRNA Synthesis, GenClip™ Long RNA Synthesis, or a tailored combination of platforms.
Solid-Phase Synthesis
Best for: Rapid Development
Scale Range: μg to several kg/batch
Key Advantage: Established platform, rapid development
AJIPHASE™ Synthesis
Best for: Large-Scale Manufacturing
Scale Range: Grams to 200 kg/batch
Key Advantage: Scalable and sustainable manufacturing
Quality, Expertise, and Manufacturing Scale
Our quality systems support GMP operations through controlled batch record documentation and QA/QC oversight. We also support stability programs designed in accordance with ICH guidelines and provide CMC regulatory support throughout the product lifecycle, including documentation, technical input, and data packages for IND, NDA, and BLA submissions. This quality foundation is backed by decades of oligonucleotide expertise, global GMP manufacturing, and scalable production capabilities.
25+
Years of oligo synthesis expertise
3
GMP Sites across Belgium & Japan
200 kg
Max AJIPHASE™ synthesis scale per batch
8,000L
Largest reactor used in GMP manufacturing
Manufacturing Facilities
Three GMP-capable sites across Belgium and Japan, providing geographic reach and manufacturing flexibility for global programs.
Wetteren, Belgium
- Scale from grams to 200 kg/batch
- GMP manufacturing experience with AJIPHASE™
- Designed for efficient scale-up and commercial manufacturing
- Seamless process and analytical development across all stages
Osaka, Japan
- 25+ years of oligonucleotide synthesis expertise
- PMDA audited
- Research-grade, process and analytical development, GMP, commercial solid-phase manufacturing
Tokai, Japan
- Scale from grams to 200 kg/batch
- GMP manufacturing experience with AJIPHASE™
- FDA and PMDA audited
- Seamless process and analytical development across all stages
Oligonucleotide Products & Consumables
We offer a range of oligonucleotide-related products and services to support research and development needs.
Custom Synthesis Products
Order directly or through your distributor based on your quotation. If you do not yet have a quotation, complete the request form to get started.
Clinical Trial Products
Submit an inquiry with your product needs. Our team will review your request and guide you through the next steps.
miRNA Design Products
Provide the miRNA ID or number, required quantity, and purification grade through the inquiry form. Once you receive a quotation, place your order directly or through your distributor.
CpG-ODN Solutions
Specify the CpG type and quantity you require through the inquiry form. Once you receive a quotation, place your order directly or through your distributor.
Life Science Products
For sample requests, submit the product number through the inquiry form. To place an order, contact your distributor with the product number and required quantity.
Let’s Discuss Your Oligonucleotide Program
From first synthesis to commercial supply — one partner, the right platform, every scale.
Frequently Asked Questions
What oligonucleotide types can Ajinomoto Bio-Pharma Services manufacture at GMP scale?
Ajinomoto Bio-Pharma Services supports GMP manufacturing for a broad range of oligonucleotides, including ASOs, siRNAs, oligonucleotide conjugates, and other modalities. They can also support sgRNA manufacturing. If you have a specific modality or design in mind, contact the Aji Bio-Pharma team to discuss the best manufacturing approach for your program.
What is AJIPHASE™ and how does it differ from traditional solid-phase oligonucleotide synthesis?
AJIPHASE™ is Ajinomoto Bio-Pharma Services’ proprietary liquid-phase synthesis technology for oligonucleotides and peptides. Instead of the resin used in solid-phase synthesis, AJIPHASE™ uses a proprietary soluble anchor, enabling highly efficient reactions, simpler scale-up, and robust process control.
What is the maximum scale for GMP oligonucleotide synthesis at Ajinomoto Bio-Pharma Services?
For solid-phase, Ajinomoto Bio-Pharma Services supports manufacturing from μg to kg per batch scale. With AJIPHASE™, Aji Bio-Pharma can support production up to 200 kg per batch, with larger-scale options available. This flexible platform allows Aji Bio-Pharma to match the manufacturing approach to your development stage and commercial needs.
Can Ajinomoto Bio-Pharma Services support both non-GMP research synthesis and GMP clinical manufacturing?
Yes. Ajinomoto Bio-Pharma Services supports programs from small-scale non-GMP material for early research use through GMP manufacturing for clinical development and beyond. With capabilities across multiple production scales, Aji Bio-Pharma provides a seamless handoff from early to late development stage, allowing you to work with a single partner throughout your program.
What modified oligonucleotide chemistries does Ajinomoto Bio-Pharma Services support?
Ajinomoto Bio-Pharma Services supports a wide range of modified oligonucleotide chemistries, including commonly used modifications such as PS, 2′-F, 2′-OMe, 2′-MOE, LNA, and cEt. Aji Bio-Pharma also has experience with chemistries such as BNA, AmNA, GuNA, 5′-CP, and 5′-VP. For more complex modification options, contact the Aji Bio-Pharma team.
Does Ajinomoto Bio-Pharma Services support IND CMC filing for oligonucleotide drug substances?
Yes. Drawing on experience from more than 50 GMP manufacturing campaigns and extensive support for programs advancing from preclinical to early clinical stages, Ajinomoto Bio-Pharma Services can support IND CMC activities for oligonucleotide API. Aji Bio-Pharma’s services include quality design, process and analytical development, and preparation support for IND-related documentation.
Can Ajinomoto Bio-Pharma Services manufacture oligonucleotide conjugates, including GalNAc and AOC?
Yes. Ajinomoto Bio-Pharma Services supports the manufacture of oligonucleotide conjugates, including GalNAc-conjugated oligonucleotides and AOC programs. For AOCs, Aji Bio-Pharma can support both AJICAP™, proprietary site-specific conjugation technology, and conventional random conjugation approaches, depending on program needs.