VHH Antibody Manufacturing
Our VHH development and manufacturing services support programs from early strain development and expression screening through process development and GMP production, using CORYNEX™ microbial expression technology to enable efficient production of active, properly folded proteins.
Supporting VHH Programs Across Development Stages
From strain development and process optimization through technology transfer and GMP manufacturing, our capabilities support protein programs as they progress toward clinical and commercial supply.
Strain Development
Strain engineering is tailored to the specific VHH sequence, with expression and secretion confirmation and initial titer and purity assessment to establish a foundation for further development.
Process Development & Scale-Up
Upstream and downstream process optimization, analytical method development, and scale-up strategy aligned with the target GMP manufacturing facility.
Technology Transfer & GMP Manufacturing
Technology transfer to a qualified partner CDMO supports GMP batch manufacturing, release testing, and stability, with our experts providing technical oversight for clinical and commercial supply.
The Benefits of CORYNEX™
A microbial expression platform designed to secrete VHHs in active, properly folded form.
Disulfide Bond Integrity
Target proteins are secreted directly into the culture medium in a properly folded form, supporting correct disulfide bond formation and biological activity.
No Refolding Required
Because target proteins are secreted directly into the culture medium rather than accumulated intracellularly as inclusion bodies, refolding is not required.
Endotoxin-Free
CORYNEX™ uses the Gram-positive bacterium C. glutamicum, eliminating the LPS endotoxin burden associated with E. coli-based expression and the need for endotoxin removal.
Simplified Purification
Cleaner starting material and the absence of LPS can reduce downstream purification requirements.
Higher Yields
Titers exceeding 10 g/L, combined with shorter fermentation times, can support high process productivity.
Fewer Steps from Fermentation to Final Product
By eliminating the need for protein refolding and endotoxin (LPS) removal, protein secretion enables a streamlined workflow that moves directly from fermentation to chromatography. This simplified, highly scalable process maximizes purity and overall recovery through fewer purification steps, significantly driving down per-gram manufacturing costs while accelerating timelines to the final drug substance.
Let’s Discuss VHH Antibody
Manufacturing for Your Program
Endotoxin-free. Properly folded. No refolding required. From feasibility to GMP.