AJIPHASE™ for Peptides
AJIPHASE™ provides a scalable manufacturing platform for peptides, particularly high-volume therapeutics such as GLP-1 analogs and complex structures such as multi-cyclic peptides. The liquid-phase process enables efficient large-scale production with reduced amino acid, reagent, and solvent consumption while utilizing standard chemical manufacturing equipment.
The AJIPHASE™ Process for Peptides: Step by Step
AJIPHASE™ uses a proprietary hydrophobic anchor for liquid-phase peptide synthesis. Simple extraction between cycles removes by-products and excess reagents without intermediate isolation or chromatography, enabling streamlined and scalable manufacturing.
Why AJIPHASE™ for Peptides
AJIPHASE™ supports a broad range of peptide programs, with the synthesis strategy tailored to sequence and program requirements. For very short sequences or unusual chemistry, our team will recommend the most appropriate approach.
Scale When You Need It
Programs that start on AJIPHASE™ can stay on AJIPHASE™ through clinical and commercial supply. Process conditions and documentation evolve as programs scale, while the same platform is maintained — minimizing technology transfer and CMC changes.
Lower Solvent and Reagent Consumption vs. SPPS
Even at small scale, AJIPHASE™ requires fewer equivalents of activating reagents and less solvent per cycle than solid-phase synthesis. Quantifiable improvement in PMI — confirmed via our EcoPass sustainability tool.
Broad Modification Support in a Single Platform
Cyclic peptides, disulfide-bridged structures, PEGylated variants, lipidated sequences, non-natural amino acids — the modifications that define modern peptide therapeutics are all supported within the same AJIPHASE™ workflow.
Standard Equipment, Straightforward Technology Transfer
AJIPHASE™ runs in standard chemical reactors — no proprietary synthesizer hardware required. For programs moving to in-house manufacturing or partner CDMOs, technology transfer can be implemented efficiently.
A More Sustainable Path to Scale
AJIPHASE™ supports more sustainable peptide manufacturing by reducing organic solvent consumption by up to 90% compared with traditional SPPS. By lowering solvent, reagent, and raw material use, the platform helps reduce environmental impact while improving manufacturing efficiency.
Reduced Solvent Use
Simple extraction between elongation cycles reduces the need for extensive washing and chromatographic purification, significantly reducing solvent consumption compared with SPPS and contributing to a substantial reduction in Process Mass Intensity.
No Resin, Flexible Scale
A soluble anchor enables simple extraction-based processing in standard chemical reactors, supporting flexible scale-up across reactor sizes.
Let’s Discuss AJIPHASE™ for Your Program
Same process. Specialized team. Every scale.
Frequently Asked Questions
What is the difference between AJIPHASE™ and solid-phase peptide synthesis (SPPS) for peptides?
AJIPHASE™ uses a proprietary soluble anchor for solution-phase peptide synthesis, while SPPS uses a solid resin support. In AJIPHASE™, coupling and deprotection proceed in solution, with simple extraction used between elongation cycles to recover the reaction intermediate and remove by-products and excess reagents. This resin-free, solution-phase approach enables processing in standard chemical reactors, supporting flexible scale-up across reactor sizes and larger-scale manufacturing. AJIPHASE™ can also support transitions from SPPS by evaluating purity and impurity profiles and providing CMC support for the manufacturing change.
What is the maximum scale for AJIPHASE™ peptide manufacturing?
AJIPHASE™ has demonstrated GMP manufacturing experience for peptide programs, with manufacturing capabilities extending to 100+ kg per batch. Achievable scale depends on peptide characteristics, process requirements, and reactor capacity, with scale-up tailored to each program.