2023 / 04 / 28

Presentation at PEGS BOSTON

Ajinomoto Bio-Pharma Services will participate in PEGS BOSTON, on May 15 to 19, 2023.

PEGS Boston Summit is the leading biologics event with comprehensive programming covering all aspects of biologic drug development with in-depth presentations on protein and antibody engineering, immunotherapy, oncology, expression, analytics, immunogenicity, and more.

Ajinomoto Bio-Pharma Services will be making oral and poster presentations to introduce our new services and new technologies at the conference.

We look forward to your visit.

Event Name	PEGS BOSTON
Dates	May 15 (Mon) – 19 (Fri), 2023
Venue	Hynes Convention Center, 900 Boylston Street, Boston, MA 02215

Oral Presentation

Title and Presenters	“Introduction of the CDMO capability for biopharmaceutical development and CORYNEX® technology provided by Ajinomoto Bio-Pharma Services” Hayato Nagano, Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc.
Executive Summary	Ajinomoto Bio-Pharma Services as a fully integrated contract development and manufacturing organization (CDMO) offers a broad range of innovative platform technologies and the End-to-End solutions for biopharmaceutical development and manufacturing. In this presentation, we will show our CDMO capability and CORYNEX® protein expression platform technology including the site-specific incorporation of non-canonical amino acid for biopharmaceuticals.
Date, Time and Venue	May 15(Mon), 2023 9:30 AM https://www.pegsummit.com/difficult-to-express-proteins

Poster Presentation(1)

Title and Presenters	“From peptides and small proteins to mAb, Ajinomoto’s proprietary microbial platform for pharmaceutical protein production” Kazuo Yamagishi, Bio-pharma services dept., Ajinomoto Co., Inc.
Executive Summary	Using cutting-edge protein production platform, Ajinomoto provides all services from strain development to manufacturing. CORYNEX® : A bacterial recombinant protein expression system for antibody fragments and scaffolds using endotoxin-free bacteria as host. TALAMAX® : A system for the production of antibodies, scFv and Fc-fusion proteins using microbe. Compared to animal cell platform, culture time is reduced by half and the cost of fermentation raw materials is reduced to 1/10.

Title and Presenters

“From peptides and small proteins to mAb, Ajinomoto’s proprietary microbial platform for pharmaceutical protein production”
Kazuo Yamagishi, Bio-pharma services dept., Ajinomoto Co., Inc.

Executive Summary

Using cutting-edge protein production platform, Ajinomoto provides all services from strain development to manufacturing.
CORYNEX® : A bacterial recombinant protein expression system for antibody fragments and scaffolds using endotoxin-free bacteria as host.
TALAMAX® : A system for the production of antibodies, scFv and Fc-fusion proteins using microbe. Compared to animal cell platform, culture time is reduced by half and the cost of fermentation raw materials is reduced to 1/10.

Poster Presentation(2)

Title and Presenters	“Site-specific Incorporation of Non-Canonical Amino Acids by Proprietary Microbial Protein Expression System” Yumi Nagase, Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc.
Executive Summary	CORYNEX® is protein manufacturing service based on a proprietary protein expression system by Corynebacterium glutamicum of Ajinomoto Co. By integrating “CORYNEX®” and amber suppression technologies, we have succeeded in site-specific incorporation of non-canonical amino acids (ncAAs) into peptides/proteins and expanded molecular repertoire, aiming at site-specific conjugation and protein stabilization/functionalization. Here we show examples of site-specific conjugation of a chemical compound or a protein via p-azido-L-phenylalanine and protein functionalization with 3-chloro-L-tyrosine.

Title and Presenters

“Site-specific Incorporation of Non-Canonical Amino Acids by Proprietary Microbial Protein Expression System”
Yumi Nagase, Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc.

Executive Summary

CORYNEX® is protein manufacturing service based on a proprietary protein expression system by Corynebacterium glutamicum of Ajinomoto Co. By integrating “CORYNEX®” and amber suppression technologies, we have succeeded in site-specific incorporation of non-canonical amino acids (ncAAs) into peptides/proteins and expanded molecular repertoire, aiming at site-specific conjugation and protein stabilization/functionalization. Here we show examples of site-specific conjugation of a chemical compound or a protein via p-azido-L-phenylalanine and protein functionalization with 3-chloro-L-tyrosine.