Innovative liquid phase synthesis for oligonucleotide, peptide, PMO and PPMO

AJIPHASE®’s VALUE

Mass Production with High Purity

  • Achieved by hybrid process of conventional solid phase and classical liquid phase synthesis technology.

Seamless Scale Up from Lab to Commercial

  • Highly-repeatable process with no special equipment.

Green Chemistry

  • Lesser solvent and reagent consuming than traditional solid phase synthesis, making it a more eco-friendly method

Technology

AJIPHASE® is a hybrid of solid and solution phase syntheses that uses an anchor to make the molecules very soluble in non-polar solvents, providing a homogenous mixture.
After the reaction occurs, the anchor is filtered out along with the excess reagents and byproducts, providing the recovered intermediate, all in one reactor.

This advanced technology allows Ajinomoto Bio-Pharma Services to manufacture commercial quantities of various middle molecules under GMP, without sacrificing purity or quality.

AJIPHASE® is a green technology that uses less solvents and reagents than the conventional technology while still providing high yield batch sizes.

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Solid Phase Liquid Phase AJIPHASE®
Scaling up Limited Easy Easy
Quality Middle High High
Lead time Short Long Middle
Applicability
(Chain Length)
Long Short Long
Environmental impact High Middle Middle

Track Record

Quality and purity profiles show no difference between AJIPHASE® and traditional solid phase synthesis. This advanced process is highly reproducible and scalable with no additional expensive special equipment, providing cost-effective and pure PMOs, oligonucleotides and peptides. AJIPHASE® has been introduced in commercial drug substance manufacturing.


Global Service Offering

At our manufacturing facilities in Japan and Belgium, we are able to produce large scale PMOs, oligonucleotides and peptides via AJIPHASE® technology with using our GMP expertise.


Service Flow

Ajinomoto Bio-Pharma Services offers a one stop service from lab to commercial scale.


Contact Us

For further information, please contact us using the link below and an Ajinomoto Bio-Pharma Services representative will contact you.